Custom Peptides
Cayman Chemical noruscogenIn 10mg
A natural sapogenin that acts as a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (EC50 = 110 nM); up-regulates the expression of several RORα-inducible genes in the livers of mice, when given at 3 mg/kg/d orally for seven days
Cayman Chemical 20a-dIhydro PrednIsolon 10mg
A metabolite of prednisolone; has been found in the urine of cattle following ACTH administration but not in naturally stressed or non-stressed cattle
Cayman Chemical Rubmaln 10mg
A naphthohydroquinone with diverse biological activities; inhibits the growth of E. coli and S. aureus in a disc assay at 100 μg per disc; scavenges DPPH free radicals in a cell-free assay (IC50 = 0.7 μM); inhibits ACAT1 and ACAT2 (IC50s = 80 and 22 μM, respectively) and cholesterol ester synthesis (IC50 = 18 μM) in murine macrophages; increases BMP2-induced osteoblastic differentiation of C2C12 mesenchymal progenitor cells; enhances skeletal development in zebrafish larvae; inhibits TNF-α-induced NF-κB reporter gene expression and nuclear translocation of p65 and potentiates TNF-α-induced apoptosis in HeLa cells; reduces tumor growth in a HeLa mouse xenograft model at 25 and 75 mg/kg
Cayman Chemical Mangostn 10mg
A xanthone with diverse biological activities; inhibits growth of MRSA and MSSA (MICs = 6.25-12.5 and 6.25-25 μg/ml, respectively), P. falciparum (IC50 = 3 μg/ml), and M. tuberculosis (MIC = 6.25 μg/ml); inhibits FASN (IC50 = 24.83 μM); induces cell cycle arrest at the G2/M phase and intrinsic and mitochondrial apoptosis in MCF-7 breast cancer cells; inhibits LPS-induced nitric oxide and PGE2 production in RAW264.7 cells; reduces neutrophil infiltration and TNF-α and IL-1β production in a mouse model of carrageenan-induced peritonitis
Cayman Chemical Compound 401 10mg
A dual inhibitor of mTOR and DNA-PK (IC50s = 0.28 and 5.3 µM, respectively); selective for DNA-PK and mTOR over PI3K, ATM, and ATR (IC50s = >100 µM for all); inhibits phosphorylation of the mTOR targets S6K1 and Akt in Rat-1 fibroblasts and in M059J glioma cells that lack DNA-PK at 10 µM; inhibits proliferation of TSC1-/- MEFs (IC50 = 2 µM) but not TSC1+/+ MEFs; induces apoptosis in TSC1-/- MEFs
Cayman Chemical StrontIum Rnlate 10mg
An antiosteoporotic agent; inhibits 1,25-dihydroxyvitamin D3-induced increases in the levels of carbonic anhydrase II and the vitronectin receptor, markers of osteoclast differentiation, in isolated chicken bone marrow cells at 0.1, 0.5, and 1 mM; pretreatment or continuous treatment of bovine bone slices at 1 mM inhibits bone resorption by isolated rat osteoclasts; decreases osteoclast surface and number but has no effect on the bone formation rate or mineral apposition rate in the alveolar bone in adult cynomolgus monkeys at 750 mg/kg per day
Cayman Chemical RS 25344hydrochlorIde 10mg
A PDE4 inhibitor (IC50 = 0.3 nM); selective for PDE4 over PDE1, -2, and -3 (IC50s = >100 µM for all); inhibits concanavalin A-induced IL-5 release and LPS-induced TNF-α release in isolated human PBMCs (EC50s = 0.3 and 5.4 nM, respectively)
Cayman Chemical NIguldIpInhydrochlorIde 10mg
A dihydropyridine that acts as a potent, selective α1A-adrenoceptor antagonist (Ki = 0.16 nM); less potently blocks L- and T-type Ca2+ channels (IC50s = 0.4 and 0.9 µM, respectively)
Cayman Chemical MolnupIravIr 10mg
A prodrug form of EIDD-1931; reduces body weight loss, lung hemorrhage, and lung viral titers, as well as improves pulmonary function in mouse models of SARS-CoV or MERS-CoV infection when administered prophylactically at 2 hours pre-infection or therapeutically at 12 hours post-infection at 500 mg/kg; reduces shed virus load and fever in ferret models of H1N1 or H3N2 influenza A virus infection at 100 mg/kg twice per day
Cayman Chemical PseudomonIc AcId 10mg
An antibiotic; bacteriostatic against S. aureus (MIC = 0.05 UG/ml); active against skin wound clinical isolates of MRSA (MICs = 1-4 UG/ml); inhibits MRSA and P. aeruginosa biofilm formation in vitro; inhibits bacterial cell wall isoleucyl-tRNA synthetase; topical administration reduces the number of wound CFUs in a mouse model of MRSA skin infection at 2% v/v
Cayman Chemical ThIomyrIstoyl 10mg
A potent and selective SIRT2 inhibitor (IC50s = 0.028, 98, >200, and >200 μM for SIRT2, SIRT1, SIRT3, and SIRT5-7, respectively); inhibits acetyl-H3K9 peptide and NAD binding to SIRT2 and promotes c-Myc degradation in a dose-dependent manner; exhibits selective cytotoxicity (IC50s = 8.4-36.8 and >50 μM for cancerous and non-cancerous cell lines, respectively); decreases tumor volume and increases areas of necrosis in an MDA-MB-231 mouse breast cancer xenograft model; increases tumor-free survival time in a MMTV-PyMT mouse mammary tumor model
Cayman Chemical BNTXmaleate 10mg
A δ1-opioid receptor antagonist (Ki = 0.1 nM); selective for the δ1-opioid receptor over the δ2-, μ-, and κ-opioid receptors (Kis = 10.8, 13.3, and 58.6 nM, respectively); decreases proliferation of primary mouse splenic B cells and the production of IL-2 and IL-4 by primary mouse splenic T lymphocytes at 1 and 10 µM; has antinociceptive activity in the tail-flick test in mice (ED50 = 46.4 pmol/animal) and decreases the antinociceptive activity of DPDPE at 6.3 pmol/animal; decreases the number of capsaicin-induced coughs in mice at 0.3-3 mg/kg; reduces the number of parasitized red blood cells in a mouse model of chloroquine-resistant P. chabaudi infection at 10 mg/kg
Cayman Chemical SC144hydrochlorIde 10mg
A gp130 inhibitor; inhibits phosphorylation of STAT1, STAT3, and Akt induced by LIF and IL-6, but not IFN-γ, in OVCAR-8 ovarian cancer cells at 20 µM; induces cycle arrest at the G0/G1 phase in MDA-MB-435 breast and HT-29 colorectal cancer cells and inhibits proliferation of 14 cancer cell lines (IC50s = 0.4-4 µM); reduces tumor growth in OVCAR-8 and MDA-MB-435 mouse xenograft models